Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan,Haixia Zou,Wenhui Zhou,Xiaowan Yuan,Zhijun Li,Xiaodong Ma,Chang Liu,Yonghui Wang,Jessica M Rosenholm,Wenguo Cui,Xiangmeng Qu,Hongbo Zhang

BIOMATERIALS SCIENCE（2022）

引用 7|浏览10

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摘要

Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

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