Longitudinal Nitric Oxide Levels and Infections by Ultrastructure and Genotype in Primary Ciliary Dyskinesia

Massimo Pifferi,Attilio L Boner,Serena Gracci,Rossella Fonnesu, Debora Maj,Gabriele Donzelli,Angela Michelucci,Angela Cangiotti,Veronica Bertini,Angelo Valetto,Maria Adelaide Caligo,Mario Miccoli,Diego Peroni, Andrew Bush

Chest（2022）

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摘要

Lower nNO in patients with PCD with genetic and ultrastructural changes associated with greater lung function decline may be related to worse prognosis, but whether a low nNO is causal needs further study. If lower nNO directly results in a poorer prognosis, strategies augmenting upper airway nitric oxide production may be worth evaluating.

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关键词

ciliary ultrastructure,genotype,lower airway nitric oxide,nasal nitric oxide,primary ciliary dyskinesia,Pseudomonas aeruginosa,respiratory infections

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