Brain disconnectome mapping derived from white matter lesions and serum neurofilament light levels in multiple sclerosis: A longitudinal multicenter study

NeuroImage: Clinical(2022)

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摘要
•Individual disconnectome maps generated using a template of 7T MRI data.•Disconnectome maps conceptualize distal brain network aberrations.•Using lesions maps from our MS cohort, we produced individual disconnectome maps.•Serum neurofilament light levels were associated with disconnectome maps.•Voxel-wise analyses revealed interesting association with serum neurofilament light levels.
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3D BRAVO,CAT12,CIS,CLSM,DMT,DTI,EDSS,FLAIR,FSPGR,GA,GD,GLM,HC, healthy controls,IFN,IQR,MNI,MPRAGE,NfL,PBVC,PMS,PPMS,RIS,rLMM,RRMS,SIMOA,SPMS,T,T2LV,TE,TFCE,TFE,TR
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