Neural substrates of psychosis revealed by altered dependencies between brain activity and white-matter architecture in individuals with 22q11 deletion syndrome

•Function-structural dependency is altered in patients with 22q11 deletion syndrome.•Stronger dependency in subcortical regions correlates with psychotic symptoms.•Weaker dependency in cingulate cortex correlates with psychotic symptoms.•Multimodal and not unimodal indexes were correlated with psychosis emergence.