ICOS-Positive Regulatory T Cells in Hepatocellular Carcinoma: The Perspective from Digital Pathology Analysis.

Li-Chun Lu,Cecilia Deantonio,Cintia C Palu,Yi-Hsuan Lee,Laura S Mitchell,Marianne Cowan,Matthew Corser,Lorcan Sherry,Ann-Lii Cheng,Sonia Quaratino,Yu-Yun Shao,Richard C A Sainson,Chih-Hung Hsu

Oncology（2022）

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摘要

An increased abundance of ICOS+ Tregs in the tumor center in comparison to the peritumor area indicates a strong immunosuppressive tumor microenvironment of HCC. A high proportion of ICOS+Foxp3+ cells and a shorter distance between ICOS+ Tregs and other ICOS+ cells were associated with a poor OS, suggesting that depleting ICOS+ Tregs might provide clinical benefit for patients with HCC.

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关键词

Co-stimulatory receptor,Foxp3,Immune checkpoint,Immunotherapy,Liver cancer,Tumor microenvironment

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