RNA-sequencing reveals an immune “hot” gene expression signature in oropharyngeal squamous cell carcinoma which is upregulated upon decitabine treatment in cell lines

J Ezic,A von Witzleben, A Fehn,M Bens,J Thomas, O Ammerpohl, J Kolarova,H Kestler, J Kraus,J Döscher,P Schuler,J Greve, R Marienfeld,T Barth, P Möller,A Kleger,M-N Theodoraki,M Brand, C Brunner,T Hoffmann,C Ottensmeier,S Laban

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., BonnLaryngo-Rhino-Otologie（2021）

Cited 0|Views7

No score

Abstract

Content Introduction A significant percentage of oropharyngeal squamous cell carcinoma (OPSCC) is human papillomavirus (HPV) driven. HPV-positive OPSCC have a prognostic advantage likely due to cancer-specific immunity. We aimed to identify expression patterns of immune-related genes to assign “hot”and “cold” tumors.

Translated text

Key words

oropharyngeal squamous cell carcinoma,gene expression signature,gene expression,rna-sequencing

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined