An integrated pathological research for precise diagnosis of schizophrenia combining LC-MS/1H NMR metabolomics and transcriptomics

•An integrated metabolomics-transcriptomics approach has been developed.•86/189 diagnostic metabolomic/transcriptomic biomarkers are found.•Pathogenesis of schizophrenia is studied based on the biomarkers.•Characteristic metabolomic/transcriptomic spectrums are established.•Metabolomic/transcriptomic diagnostic formulas possess fine predictive abilities.