Adherence to five diet quality indices and pancreatic cancer risk in a large US prospective cohort
American Journal of Epidemiology(2022)
摘要
Abstract Few prospective studies have examined associations between diet quality and pancreatic ductal adenocarcinoma (PDAC), or comprehensively compared diet quality indices. We conducted a prospective analysis of adherence to the Healthy Eating Index (HEI)-2015, alternative HEI-2010 (AHEI-2010), alternate Mediterranean diet (aMED), and two Dietary Approaches to Stop Hypertension (DASH, Fung and Mellen) indices and PDAC within the National Institutes of Health (NIH)-AARP Diet and Health Study (United States, 1995-2011). The dietary quality indices were calculated using responses from a 124-item food frequency questionnaire completed by 535,824 (315,780 men and 220,044 women) participants. We used Cox proportional hazard regression models to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for each diet quality index and PDAC. During follow-up through 2011 (15.5-year median), 3,137 incident PDAC cases were identified. Compared to those with the lowest adherence quintiles (Q1), participants with the highest adherence (Q5) [HRs (95% CIs)] to the HEI-2015 [0.84 (0.75, 0.94)], aMED [0.82 (0.73, 0.93)], DASH-Fung [0.85 (0.77, 0.95)], and DASH-Mellen [0.86 (0.77, 0.96)] had a statistically significant lower PDAC risk but not the AHEI-2010 [0.93 (0.83, 1.04)]. This prospective observational study supports the hypothesis that greater adherence to the HEI-2015, aMED, and DASH dietary recommendations may reduce PDAC.
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