The Effects of Chronic Variable Stress and Photoperiod Alteration on the Hypothalamic–Pituitary–Adrenal Axis Response and Behavior of Mice

Lauren Miller, Mariella Bodemeier Loayza Careaga,Robert J Handa,T John Wu

Neuroscience（2022）

引用 3|浏览4

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摘要

•CVS attenuated the HPA axis reactivity in response to an acute stressor.•CVS affected physiological and behavioral parameters in both sexes.•Blunted CORT levels were related to reduced POMC mRNA expression in females.•Females and males show differences on gene expression of key HPA axis regulators.

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11βHSD1,11βOHase,ACTH,AVP,BST,CORT,CRFR1,CRH,CVS,EZM,GR,HPA,MC2R,MR,OFT,PFC,POMC,PVN,RT qPCR,SCN,SPT,TBP

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