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METTL3 Inhibits Antitumor Immunity by Targeting m6A-BHLHE41-CXCL1/CXCR2 Axis to Promote Colorectal Cancer

Huarong Chen,Yasi Pan,Qiming Zhou,Cong Liang,Chi-Chun Wong,Yunfei Zhou,Dan Huang,Weixin Liu,Jianning Zhai,Hongyan Gou,Hao Su,Xiaoting Zhang,Hongzhi Xu,Yifei Wang,Wei Kang,William Ka Kei Wu,Jun Yu

Gastroenterology（2022）

引用 52|浏览10
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摘要
METTL3 is a potential therapeutic target for colorectal cancer whose inhibition reverses immune suppression through the m6A-BHLHE41-CXCL1 axis.
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关键词
Colorectal Cancer,N6-Methyladenosine,METTL3,MDSC,Immunotherapy
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