Nanoclay-reinforced HA/alginate scaffolds as cell carriers and SDF-1 delivery-platforms for bone tissue engineering

Itsasne Erezuma,Izeia Lukin,Carolina Pimenta-Lopes,Francesc Ventura,Patricia Garcia-Garcia,Ricardo Reyes, Mª Rosa Arnau,Araceli Delgado,Nayere Taebnia,Firoz Babu Kadumudi,Alireza Dolatshahi-Pirouz,Gorka Orive

International Journal of Pharmaceutics（2022）

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摘要

•Nanoreinforced HA/Alginate scaffolds were created by a simple mixing technique.•In vitro studies haven proven C2/M2 scaffolds biocompatibility and osteogenic ability.•M2 scaffolds boost mineralization even in a differentiation-free media.•In vivo studies proved SDF-1 release and bone regeneration capacity of C2/M2 scaffolds.•C2/M2 scaffolds showed potential for bone tissue engineering purposes.

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关键词

3D Scaffold,Bone,Biomaterials,Nanoclay,Tissue Engineering,SDF-1

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