Do device-measured physical activity and sedentary behavior differ by depression symptom status in persons with multiple sclerosis?

•Depression symptoms are highly prevalent and debilitating in adults with multiple sclerosis (MS).•Reduced physical activity (PA) is a meaningful outcome of depression in MS.•Increased levels of PA can reduce depression symptoms in MS.•Disability must be considered when studying PA as an outcome of depression status.•PA should be examined in those with MS with moderate disability and depression.