Aerobic Construction of 2-Acyl Benzoxazole by Tandem C-H Oxygenation and Oxazole Ring Formation

The synthesis of useful 2-acyll)enzoxazoles has been realized via the tandem methylene C II oxygenation and.0)(azole annulation of N- 0-hy droxyphellyi)phenYlacetamides via copper eatalYsis in one-Pot fashion. Besides featuring the incomparable step-economy resulting from the multi-step transformation, the tunable synthesis of diverse 2 -methylene functiorialized belizoxazoles using identical starting materials as well as the expanded synthesis of corresponding benzotInazoles is also attractive advantage of the work.