Rheumatoid Factor Recognizes Specific Domains of the IgG Heavy Chain Complexed with HLA Class II Molecules.

Shanshan Zhang,Hideaki Tsuji,Hui Jin,Koji Kitagori,Shuji Akizuki,Ran Nakashima,Hajime Yoshifuji,Masao Tanaka,Hisashi Arase,Koichiro Ohmura,Akio Morinobu

ARTHRITIS & RHEUMATOLOGY（2023）

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摘要

The CH1 domain of IgGH binds to the RA-susceptible HLA-DR molecule and is expressed on the cell surface. RF specifically recognizes the CH3 domain of the IgGH/HLA-DR4 complex.

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关键词

RA, RF, IgG heavy chain, autoantigens and autoantibodies, major histocompatibility complex

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