Domino Reaction of Isatins with alpha-Oxoketene-N,S-acetals: An Efficient Synthesis of Pyrrolo[3,4-c]quinoline-1,3-diones and 2,3-Dihydro-1H-pyrrolo[3,4-c]quinolin-1-ones

Anup Kumar Sharma,Anjali Jaiswal,Shiv Chand,Krishna Nand Singh

ASIAN JOURNAL OF ORGANIC CHEMISTRY（2021）

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摘要

A straightforward synthesis of pyrrolo[3,4-c]quinoline-1,3-diones and 2,3-dihydro-1H-pyrrolo[3,4-c]quinolin-1-ones has been accomplished by the cascade reaction of isatins with alpha-oxoketene-N,S-acetals using BF3 . Et2O in DMSO/toluene at 110 degrees C. The reaction offers an easy access to biologically important tricyclic N-heterocycles via C-C/C-X bond formation.

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关键词

Pyrrolo[3, 4-c]quinoline-1, 3-diones, 2, 3-Dihydro-1H-pyrrolo[3, 4-c]quinolin-1-ones, BF3 . Et2O, Ketene N, S-acetals, Isatins

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