Synthesis and bioactivity evaluation of 5,6-epoxynorcantharidin mono-amide and imide derivatives

Guangliang Chen,Jiyu Gao,Wencai Huang,Zicheng Li,Yinglan Zhao

Monatshefte für Chemie - Chemical Monthly（2022）

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摘要

A series of 5,6-epoxynorcantharidin mono-amide and imide derivatives were designed and synthesized. MTT cell inhibition experiment shows that 5,6-epoxy compounds have good biological activity compared with the corresponding 5,6-olefin compounds and their hydrogenated products. Graphical abstract

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关键词

Norcantharidin derivatives, Natural products, Antitumor agents, Structure–activity relationships

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