Anticancer chiral and racemic ternary copper(II) complexes: Multiple mechanisms and epigenetic histone methyltransferase enzymes as novel targets

Cheang Wei Chan, Chin Yoong Yong, How Mun Chang,Pei Ying Ng,Fabian Davamani,Ebenezer Chitra, Vannajan Sanghiran Lee,Kong Wai Tan,Mohd Jamil Maah,Chew Hee Ng

Polyhedron（2022）

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摘要

Anticancer property of [Cu(phen)(L-ala)(H2O)]NO3 1, its racemic 2 and its racemic product 3 towards MDA-MB-231 and screening results of 3 on NCI 60 cancer cell lines are reported herein. Role of EZH1/EZH2 epigenetic enzymes in breast cancer cells, and docking of enantiomers of [Cu(phen)(ala)(H2O)]+ in proteasome are also presented.

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关键词

Ternary copper(II)-phenanthroline complexes,Racemic anticancer agents,Multiple targeting,Breast cancer,Histone-lysine N-methyltransferase enzyme,Drug resistance

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