Protective effect and mechanism of betaine against hyperosmotic stress in porcine intestinal epithelium

Shuyi Xu,Shiyi Lu,Haichao Wang,Sisi Li,Jie Feng

Journal of Functional Foods（2021）

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摘要

•Betaine exerts osmoprotective role in small intestine.•Betaine ameliorated hyperosmotic stress induced cell shrinkage and elevation ROS of intestinal epithelium.•Betaine attenuated mitochondria-related apoptosis caused by hyperosmolarity via maintaining mitochondrial homeostasis.•Betaine alleviated hyperosmolarity-induced autophagy with the decrease of autophagosomes and autolysosomes.

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关键词

Betaine,Hyperosmotic stress,ROS,Apoptosis,Autophagy,Porcine intestinal epithelium

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