Small organic osmolytes accelerate actin filament assembly and stiffen filaments
Biophysical Journal(2022)
摘要
Actin filament assembly and mechanics are crucial for maintenance of cell structure, motility, and division. Actin filament assembly occurs in a crowded intracellular environment consisting of various types of molecules, including small organic molecules known as osmolytes. Ample evidence highlights the protective functions of osmolytes, including their effects on protein stability and their ability to counteract cellular osmotic stress. Recently, one such osmolyte, trimethylamine-N-oxide (TMAO), has been shown to modulate actin filament assembly based on bulk fluorescence assays.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要