The theoretical study of dynein motility regulated by tubulin post translational modification

The microtubules that form the cytoskeletons of eukaryotic cilia and flagella are doublet microtubules composed of A- and B-tubules. It is known that dynein-2 and kinesin-2, responsible for the transportation in cilia and flagella, walk on A-tubules and B-tubules, respectively. However, it is unknown how dynein-2 and kinesin-2 select A-tubules and B-tubules, respectively, while both A- and B-tubules are composed of the same alpha- and beta-tubulin dimer. Recent studies indicate that tubulin post-translational modifications (PTMs) are mostly enriched in the B-tubules.