Therapeutic implication of SOX9 and YAP1 co-repression in advanced intrahepatic cholangiocarcinoma.

Shikai Hu,Laura Molina,Junyan Tao,Silvia Liu,Mohammed Hassan,Sucha Singh,Minakshi Poddar,Kari Nejak-Bowen,Michael Oertel,Reben Raeman,Aatur Singhi,Aaron Bell,Satdarshan P Monga,Sungjin Ko

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

We elucidate the critical, but distinct roles of Yap1and Sox9 in iCCA development and demonstrate the therapeutic potential of simultaneous targeting both for wide range of iCCA irrespective of drivers. Ongoing work will comprehensively delineate the molecular mechanism how YAP1 and SOX9 compensate each other when either is removed in iCCA, and will be relevant for studying adaptive resistance against the singular targeting of SOX9 or YAP1 in iCCA.

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