Dissecting breathing control dysregulation in neonatal sepsis.

Taken together, these results shows that the ventilatory response is detrimentally affected in neonatal sepsis within only a few hours of an inflammatory insult. Not only the ability to sense O /CO levels and to respond accordingly is disrupted, but also the central respiratory rhythmic activity in preBötC slices. Both TLRs ligands induced a strong innate immune response in the brainstem which is amplified in neurons especially in pups treated with TLR1/2 ligand.