Sexual Dimorphism in Response to Vitamins B3, B9 and B12, Used in Combination, in a Mice Model of Heart Failure Induced by Pressure Overload.

Our pilot study suggests a sexual dimorphism in the response to BVit treatment in experimental HF. Indeed, the benefit of BVit treatment is only shown in females with a delay in the mortality rate associated with improved cardiac function and normalisation of lipid disturbances. To explore and understand the mechanisms underlying this sexual dimorphism, the lipid profile hypothesis appears as a relevant avenue to explore in the future.