Genomic Rearrangement in Non-coding Region of Chromosome 1 Leads to Spontaneous Obesity and Heart Failure with Preserved Ejection Fraction.

Donnell D White,Jian Wu,Lothar Lauterboeck,Robert Kesterson,Qinglin Yang

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

We conclude that the metabolic and cardiac phenotypes in the FEI mice closely recapitulate obese patients who suffer from HFpEF. Further studies on these mice should yield novel and translational insight into the genetic and metabolic mechanisms underlying the development of obesity and HFpEF, improving patient treatments.

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