Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder

Itaru Kushima,Masahiro Nakatochi,Branko Aleksic,Takashi Okada,Hiroki Kimura,Hidekazu Kato,Mako Morikawa,Toshiya Inada,Kanako Ishizuka,Youta Torii,Yukako Nakamura,Satoshi Tanaka,Miho Imaeda,Nagahide Takahashi,Maeri Yamamoto,Kunihiro Iwamoto,Yoshihiro Nawa,Nanayo Ogawa,Shuji Iritani,Yu Hayashi,Tzuyao Lo,Gantsooj Otgonbayar,Sho Furuta,Nakao Iwata,Masashi Ikeda,Takeo Saito,Kohei Ninomiya,Tomo Okochi,Ryota Hashimoto,Hidenaga Yamamori,Yuka Yasuda,Michiko Fujimoto,Kenichiro Miura,Masanari Itokawa,Makoto Arai,Mitsuhiro Miyashita,Kazuya Toriumi,Kazutaka Ohi,Toshiki Shioiri,Kiyoyuki Kitaichi,Toshiyuki Someya,Yuichiro Watanabe,Jun Egawa,Tsutomu Takahashi,Michio Suzuki,Tsukasa Sasaki,Mamoru Tochigi,Fumichika Nishimura,Hidenori Yamasue,Hitoshi Kuwabara,Tomoyasu Wakuda,Takahiro A Kato,Shigenobu Kanba, Hideki Horikawa,Masahide Usami,Masaki Kodaira,Kyota Watanabe,Takeo Yoshikawa,Tomoko Toyota,Shigeru Yokoyama,Toshio Munesue,Ryo Kimura,Yasuko Funabiki,Hirotaka Kosaka,Minyoung Jung,Kiyoto Kasai,Tempei Ikegame,Seiichiro Jinde,Shusuke Numata,Makoto Kinoshita,Tadafumi Kato,Chihiro Kakiuchi,Kazuhiro Yamakawa,Toshimitsu Suzuki,Naoki Hashimoto,Shuhei Ishikawa,Bun Yamagata,Shintaro Nio,Toshiya Murai,Shuraku Son,Yasuto Kunii,Hirooki Yabe,Masumi Inagaki,Yu-Ichi Goto, Yuto Okumura, Tomoya Ito,Yuko Arioka,Daisuke Mori,Norio Ozaki

Biological Psychiatry（2022）

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摘要

BD and SCZ/ASD differ in terms of CNV burden, characteristics of CNVs linked to neurodevelopmental disorders, and regulatory CNVs. On the other hand, they have shared molecular mechanisms, including chromatin biology. The BD risk genes identified here could provide insight into the pathogenesis of BD.

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关键词

Autism spectrum disorder,Bipolar disorder,Chromatin biology,Copy number variation,Cross-disorder analysis,Schizophrenia

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