Hippocampal Neurogenesis in Aging and Alzheimer's Disease.

Ahmed Disouky,Matthew K. Tobin,William G. Honer,Namhee Kim,Robert J. Dawe,David A. Bennett,Konstantinos Arfanakis,Orly Lazarov

BIOLOGICAL PSYCHIATRY（2022）

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摘要

Studies in rodents suggest that hippocampal neurogenesis persists throughout life. However, the existence and extent of neurogenesis in the aging and Alzheimer’s disease (AD) human hippocampus has been a topic of debate. The goal of this study was to determine the fate of hippocampal neurogenesis in mild cognitive impairments (MCI) and AD.

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Alzheimer's Disease,Hippocampal Progenitor Cells,Human Brain,Learning and Memory,Hippocampal Neuroplasticity

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