Cognitive functioning and hippocampal connectivity in patients with longstanding type 1 diabetes and apolipoprotein E 4 Short title: Cerebral effects of APOE-4 in T1DM

1 Department of Medical Psychology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands 2 Amsterdam Diabetes Center / Department of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands 3 Instituto Estadual do Cérebro Paulo Niemeyer, Center for Epilepsy, Rio de Janeiro, RJ, Brazil 4 Department of Neurology, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil 5 Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands 6 Institute of Neurology and Healthcare Engineering, University College London, London, United Kingdom 7 Department of Ophthalmology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands 8 Department of Medical Psychology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands † Deceased