Development and Validation of Blood-Based Predictive Biomarkers for Response to PD-1/PD-L1 Checkpoint Inhibitors: Evidence of a Universal Systemic Core of 3D Immunogenetic Profiling across Multiple Oncological Indications.

Ewan Hunter,Matthew Salter,Ryan Powell, Ann Dring,Tarun Naithani, Maria Eleni Chatziioannou, Abel Gebregzabhar, Mutaz Issa,Jayne Green,Serene Ng,Chun Ren Lim,Cheah Soon Keat,Ang Tick Suan,Rakesh Raman,Ho Kean Fatt, Fabian Lee Wei Luen,Heba Alshaker,Dmitri Pchejetski,Dave Blum,Thomas Guiel,Robert Heaton, Jedd Levine,Alexandre Akoulitchev

medRxiv（2023）

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摘要

This study demonstrates that a 3D genomic approach can be used to develop a predictive clinical assay for response to PD-1/PD-L1 checkpoint inhibition in cancer patients.

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关键词

immuno-oncology, immune checkpoint inhibitors, response to treatment, epigenetics, blood test

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