Intra-Chromosomal Potentials from Nucleosomal Positioning Data

No systematic method exists to derive intra-chromosomal potentials between nucleosomes along a chromosome consistently across a given genome. Such potentials can yield information on nucleosomal ordering, thermal as well as mechanical properties of chromosomes. Thus, indirectly, they shed light on a possible mechanical genomic code along a chromosome. To develop a method yielding effective intrachromosomal potentials between nucleosomes a generalized Lennard-Jones potential for the parameterization is developed based on nucleosomal positioning data. This