ADAMTS12 promotes migration and epithelial-mesenchymal transition and predicts poor prognosis for pancreatic cancer.

Rui-Zhe He,Jia-Hao Zheng,Hong-Fei Yao,Da-Peng Xu,Min-Wei Yang,De-Jun Liu,Yong-Wei Sun,Yan-Miao Huo

Hepatobiliary & pancreatic diseases international : HBPD INT（2023）

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摘要

ADAMTS12 is a crucial member of ADAMTSs in PDAC and a predictor of poor prognosis. Additionally, based on its impacts on migration and metastasis in PDAC and the relationship with EMT, ADAMTS12 plays a role of an oncogene in PDAC and may be a promising target for treatment.

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关键词

ADAMTS12,Epithelial-mesenchymal transition,Migration,Pancreatic ductal adenocarcinoma,Prognosis

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