Stimulation of the EP 3 receptor causes lung oedema by activation of TRPC6 in pulmonary endothelial cells.

Tian Jiang,Rudi Samapati, Sergej Klassen,Disi Lei,Lasti Erfinanda,Vera Jankowski,Szandor Simmons,Jun Yin,Christoph Arenz,Alexander Dietrich,Thomas Gudermann,Dieter Adam,Michael Schaefer,Joachim Jankowski,Veit Flockerzi,Rolf Nüsing,Stefan Uhlig,Wolfgang M Kuebler

The European respiratory journal（2022）

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摘要

EP activation triggers pulmonary oedema G-dependent activation of PLC and subsequent SrcFK-dependent tyrosine phosphorylation of TRPC6. In PAF-induced lung oedema, this TRPC6 activation coincides with ASMase-dependent caveolar recruitment of TRPC6, resulting in rapid endothelial Ca influx and barrier failure.

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