Genomics-driven screening for causal determinants of suicide attempt.

Adrian I Campos,Luis M Garcia-Marin,Helen Christensen,Philip J Batterham,Laura S van Velzen,Lianne Schmaal,Jill A Rabinowitz,Neda Jahanshad,Nicholas G Martin,Gabriel Cuellar-Partida,Douglas Ruderfer,Niamh Mullins,Miguel E Rentería

The Australian and New Zealand journal of psychiatry（2023）

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摘要

Suicide attempt risk is likely explained by a combination of behavioural phenotypes and risk for both physical and psychiatric disorders. Our results also suggest that substance use behaviours and pain-related conditions are associated with an increased suicide attempt risk, elucidating important causal mechanisms that underpin this significant public health problem.

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关键词

Suicide,causal inference,complex traits,genetics,risk factors

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