Obesity III: Obesogen assays: Limitations, strengths, and new directions

Biochemical Pharmacology(2022)

引用 13|浏览22
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摘要
•There are increasing novel capabilities to identify and assess obesogens.•There is still a reliance on using well-defined models with unclear translation to human health.•There is still a need for comprehensive validations of novel metabolic health models.•Computational models show some promise in future predictions and assessments of obesogens.
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US,WAT,PPARγ,SREBP-1,LXRα,GR,RXRα/β,ERα,HPAd,SGBS,MSCs,hMADS,TAFLD,NAFLD,DMSO,PHH,CYP,AhR,CAR,PXR,DEHP,DDT,BPA,PCBs,TBBPA,dpf,EDCs,IPCs,BAT,UCP1,OLTAM,ODD,HIF1α,QSAR,Tox21,OECD,NAMs,AOPs,IATAs,NIEHS,PEPPER
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