Computational biomechanical modeling of fibrin networks and platelet-fiber network interactions

Fibrin deformation and interaction of fibrin with other blood components play critical roles in hemostasis and thrombosis. In this review, computational and mathematical biomechanical models of fibrin network deformation and contraction at different spatio-temporal scales as well as challenges in developing and calibrating multiscale models are discussed. The long standing challenges include careful evaluation of the applicability of models to identify and test potential mechanisms of the biomechanical processes mediating interactions between platelets and fiber networks in blood clot stretching and contraction. Also, there is a need to use modeling approaches to determine how exactly structural and mechanical properties of major blood clot components can influence biomechanical responses of the entire clot subjected to external forces, such as blood flow or vessel wall deformations.