Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes.

Evelyn Houtman,Margo Tuerlings,H Eka D Suchiman,Nico Lakenberg,Frederique M F Cornelis,Hailiang Mei,Demiën Broekhuis,Rob G H H Nelissen,Rodrigo Coutinho de Almeida,Yolande F M Ramos,Rik J Lories, Luis J Cruz,Ingrid Meulenbelt

Rheumatology (Oxford, England)（2022）

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摘要

Treatment with the deiodinase inhibitor IOP reduced detrimental changes of injurious mechanical stress. In addition, we identified that its mode of action was likely on metabolic processes, cell proliferation and differentiation.

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关键词

DIO2,OA,cartilage,chondrocytes,iopanoic acid,mechanical stress,thyroid signalling

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