Combination of system biology and classical approaches for developing biorefinery relevant lignocellulolytic Rasamsonia emersonii strain

•Classical and integrated system biology tools to develop hyper-cellulolytic strain.•Comparative analysis of wild and developed strain at proteome and transcriptional level.•Efficient hydrolysis of acid pre-treated rice straw slurry by developed enzyme.•Spiking of developed enzyme with LPMO from M. thermophiloides from enhanced hydrolysis.