Bone marrow mesenchymal stem cells-derived exosomal microRNA-16-5p restrains epithelial-mesenchymal transition in breast cancer cells via EPHA1/NF-κB signaling axis

Yuan Zhang,Xiaofeng Lai,Qingfang Yue,Fei Cao,Yue Zhang,Yang Sun,Jun Tian, Yizhao Lu,Li He,Jun Bai,Yifang Wei

Genomics（2022）

引用 8|浏览10

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摘要

•Low miR-16-5p and high EPHA1 expression present in breast cancer.•BMSCs-derived exosomes deliver miR-16-5p to inhibit EMT in breast cancer.•MiR-16-5p targets EPHA1.•Down-regulated miR-16-5p or up-regulated EPHA1 activated NF-κB signaling.•Knockdown of EPHA1 or inhibition of NF-κB signaling reversed the effects of down-regulated miR-16-5p on breast cancer cell.

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关键词

Breast cancer,MicroRNA-16-5p,Erythropoietin-producing hepatocellular A1,Nuclear factor-κB signaling,Epithelial-mesenchymal transition

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