Proapoptotic effect of WS-299 induced by NOXA accumulation and NRF2-counterbalanced oxidative stress damage through targeting RBX1-UBE2M interaction in gastric cancer
SSRN Electronic Journal（2024）
摘要
WS-299 binds to RBX1 and disrupts the interaction of RBX1–UBC2M, thus causing selective inhibition of CUL3/5 neddylation and the collapse of neddylation complex.
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关键词
Cullin neddylation,RBX1-UBE2M interaction,NOXA accumulation,Nrf2,Gastric cancers
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