BETTER OUTCOMES AND VALUE FOR MONEY WITH COST-EFFECTIVENESS MODELLING OF CASCADE SCREENING STRATEGIES FOR FAMILIAL HYPERCHOLESTEROLAEMIA

Cascade screening for familial hypercholesterolaemia (FH) refers to the systematic testing of relatives of people known to have FH (termed ‘indexes’). Cascade screening is cost-effective compared to no screening, but alternative screening strategies have not been studied. Our objective was to identify the cost-effective strategy to select indexes to cascade, and to contacting and testing their relatives.