The Antimalarial Drug Pyronaridine Inhibits Topoisomerase II in Breast Cancer Cells and Hinders Tumor Progression In Vivo .

Paulina J Villanueva,Denisse A Gutierrez,Lisett Contreras,Karla Parra,Aldo Segura-Cabrera,Armando Varela-Ramirez,Renato J Aguilera

Clinical cancer drugs（2021）

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摘要

The findings provide evidence that PND is a topoisomerase II inhibitor and can hinder cancer progression in an animal model, further demonstrating PND's favorable characteristics as a repurposed anticancer drug.

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关键词

Anticancer,anticancer drug combination,breast cancer,drug discovery,drug repurposing,in-vivo tumor,multidrug resistance,topoisomerase

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