Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression

•Tract volume and number of tracts are reduced in the left slMFB.•Those microstructural alterations are related to depression severity and anhedonia.•There is increased VTA-PFC functional connectivity in depression.•Those increases are more pronounced in patients with severe anhedonia.•Our results extend pathophysiological models of anhedonia in depression.