Post-transplant malignancies show reduced T-cell abundance and tertiary lymphoid structures as correlates of impaired cancer immunosurveillance.

Rabi R Datta,Simon Schran,Oana-Diana Persa,Claire Aguilar,Martin Thelen,Jonas Lehmann,Maria A García-Marquez,Kerstin Wennhold,Ella Preugszat,Peter Zentis,Michael S von Bergwelt-Baildon,Alexander Quaas,Christiane J Bruns,Christine Kurschat,Cornelia Mauch,Heike Löser,Dirk L Stippel,Hans A Schlößer

Clinical cancer research : an official journal of the American Association for Cancer Research（2022）

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摘要

Our study demonstrates the impact of immunosuppression on the TME and supports impaired cancer immunosurveillance as important cause of post-transplant cancer. Modern immunosuppressive protocols and cancer therapies should consider the distinct immune microenvironment of post-transplant malignancies.

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