Surface co-deposition of polypyrrole nanoparticles and tannic acid for photothermal bacterial eradication

Bacterial infections on implantable materials can cause severe complications for affected patients, posing a serious threat to human health. Therefore, the development of appropriate surface modification strategies to construct the antibacterial platforms on medical implants are urgently needed. In this work, the poly(vinyl alcohol) (PVA)-stabilized polypyrrole nanoparticles (PVA-PPy NPs) were prepared by oxidative polymerization using FeCl3 as the oxidant. Subsequent mixing of the PVA-PPy NPs solution mixture with tannic acid (TA) was facilitated by hydrogen bonding. The as-formed TA/PVA-PPy NPs can be deposited with good adhesion onto solid materials in a substrate-independent manner. The hydrophilic TA/PVA-PPy NPs-deposited titanium (Ti-TPP) surface can reduce the adhesion of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). In addition, the Ti-TPP surface had photothermal property under 808 nm near-infrared (NIR) irradiation, which can kill the adhered bacteria via the hyperthermal effect. Upon exposure to NIR, the respective survival rates of S. aureus and E. coli on the Ti-TPP surfaces were only 1.66% and 2.78%, in comparison to those on the pristine Ti surfaces. Furthermore, the Ti-TPP surface could prevent the formation of early-stage biofilm under NIR irradiation. The TA/PVA-PPy NPs composites can be utilized as a contact-photoactive antibacterial coating for biomedical applications.