Open facility of functional genomics aimed at disclosing late-onset Alzheimer's disease epigenetic mechanisms and biomarkers.

Our protocol allows us to discern patients with severe dementia from healthy people, identifying differences in H3K4me3 profile. Next goal will be to analyse more histone marks and to intersect these data with gene expression. Moreover, being open to world-wide collaborations, we are starting to process human PBMC samples from Lee-Way Neuropathology Lab (UC Davis) with the final goal to correlate the epigenetic signature of AD brains with the expression profile in PBMC from AD patients.