Abnormal resting-state local spontaneous functional activity in irritable bowel syndrome patients: A meta-analysis

•Thepresent study isthefirst meta-analysisto investigatethefunctional changes ofthe regional brain in patients with IBS, based on the ALFF, fALFF, ReHo and DC of rs-fMRI•In the included studies of IBS, the abnormalities in the left CAL, right PoCG, left cerebellum,leftACG,rightSMGandrightMFGaremostconsistent.•The findings are complementary to the pathogenesis of IBS, and provide additional evidence for the involvement of these brain regions dysfunction in the pathophysiologyofIBS