The role of junctional adhesion molecule-C in trophoblast differentiation and function during normal pregnancy and preeclampsia

Chenrui Cao,Yimin Dai,Zhiyin Wang,Guangfeng Zhao,Honglei Duan,Xiangyu Zhu,Jingmei Wang,Mingming Zheng,Qiao Weng,Limin Wang,Wenjing Gou,Haili Zhang,Chanjuan Li,Dan Liu,Yali Hu

Placenta（2022）

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摘要

•JAM-C is highly expressed on CTBs and downregulated with gestation advance.•JAM-C expression is upregulated in EVTs of with PE patients.•JAM-C restrains trophoblast differentiation, invasion and migration.•JAMC-induced mouse model exhibits a preeclampsia-like phenotype.

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关键词

JAM-C,Trophoblast differentiation,Trophoblast invasion,Preeclampsia,β-catenin

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