Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response
Alexandra M. Zaborowski,Ahmed Abdile,Michel Adamina,Felix Aigner, Laura D'Allens,Caterina Allmer, Rocio Anula, Mihailo Andric,Sam Atallah,Simon Bach,Miklosh Bala, Marie Barussaud, Augustinas Bausys,Andrew Beggs,Felipe Bellolio,Melissa-Rose Bennett,Anton Berdinskikh, Vicki Bevan,Sebastiano Biondo,Gabriele Bislenghi, Marc Bludau,Nelleke Brouwer,Carl Brown,Christiane Bruns,Daniel D. Buchanan,Pamela Buchwald, Jacobus W. A. Burger,Nikita Burlov, Michela Campanelli, Maylis Capdepont,Michele Carvello,Hwee-Hoon Chew,Dimitri Christoforidis,David Clark,Marta Climent, Rowan Collinson,Kyle G. Cologne, Tomas Contreras,Roland Croner, IanR Daniels,Giovanni Dapri,Justin Davies,Paolo Delrio,Quentin Denost,Michael Deutsch,Andre Dias,Evgeniy Drozdov,Daniel Duek,Malcolm Dunlop,Adam Dziki, Aleksandra Edmundson,Sergey Efetov,Alaa El-Hussuna,Brodie Elliott, Sameh Emile,Eloy Espin-Basany,Martyn Evans,Seraina Faes,Omar Faiz,Nuno Figueiredo,Fergal Fleming,Caterina Foppa,George Fowler,Matteo Frasson, Tim Forgan,Frank Frizelle, Shamil Gadaev, Jose Gellona,Tamara Glyn, Barisic Goran,Emma Greenwood,Marianne G. Guren, Stephanie Guillon,Ida Gutlic,Dieter Hahnloser,Heather Hampel, Ann Hanly,Hirotoshi Hasegawa,Lene Hjerrild Iversen,Andrew Hill,James Hill,Jiri Hoch,Roel Hompes, Luis Hurtado, Fabiano Iaquinandi,Ugne Imbrasaite, Rumana Islam,Mehrenah D. Jafari,Yukihide Kanemitsu,Aleksei Karachun,Ahmer A. Karimuddin,Deborah S. Keller,Justin Kelly, Rory Kennelly,Gleb Khrykov,Petr Kocian,Cherry Koh,Neils Kok, Katrina A. Knight,Joep Knol,Christos Kontovounisios, Hartwig Korner, Zoran Krivokapic, Irmgard Kronberger, Hidde MaartenKroon,Marius Kryzauskas, Said Kural,Miranda Kusters,Zaher Lakkis, Timur Lankov,David Larson, Kai-Yin Lee,Suk Hwan Lee, Anna Lepisto, Christopher Lieu, Lynette Loi,Craig Lynch, Helene Maillou-Martinaud,Annalisa Maroli,Sean T. Martin, Anna Martling, Klaus E. Matzel,Julio Mayol,Frank McDermott, Guillaume Meurette,Monica Millan, Martin Mitteregger, Andrei Moiseenko,John R. T. Monson, Stefan Morarasu, Konosuke Moritani, Martino Munini,Caio Nahas, Sergio Nahas,Ionut Negoi, Anastasia Novikova, Misael Ocares,Koji Okabayashi,Alexandra Olkina, Luis Onate-Ocana,Jaime Otero, Cihan Ozen,Ugo Pace, Guilherme Pagin Sao Juliao, Lidiia Panaiotti,Yves Panis,Demetris Papamichael,Swati Patel, Sze-Lin Peng,Miguel Pera,Rodrigo O. Perez, Alexei Petrov, Frank Pfeffer, Terry P. Phang,Tomas Poskus,Heather Pringle,David Proud, Ivana Raguz, Nuno Rama, Shahnawaz Rasheed,Manoj J. Raval, Daniela Rega, Christoph Reissfelder, Juan Carlos Reyes Meneses, Frederic Ris,Stefan Riss, Homero Rodriguez-Zentner, Campbell S. Roxburgh,Avanish Saklani, Tarik Sammour,Deborah Saraste,Martin Schneider,Ryo Seishima,Aleksandar Sekulic,Toni Seppala, Kieran Sheahan, Alexandra Shlomina,Guiseppe Sica,Tongplaew Singnomklao, Leandro Siragusa,Neil Smart, Alejandro Solis-Pena,Antonino Spinelli, Roxane D. Staiger,Michael J. Stamos,Scott Steele, Ker-Kan Tan,Pieter J. Tanis,Paris Tekkis, Biniam Teklay,Sabrina Tengku,Petr Tsarkov,Matthias Turina,Alexis Ulrich, Bruna B. Vailati, Meike van Harten,Cornelis Verhoef,Satish Warrier, Steven Wexner, Hans de Wilt,Benjamin A. Weinberg, Cameron Wells, Albert Wolthuis, Evangelos Xynos, Nancy You, Alexander Zakharenko, Justino Zeballos,Youzhi Zhou,Des C. Winter
BRITISH JOURNAL OF SURGERY（2022）
引用 6|浏览12
摘要
In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated with a reduced likelihood of nodal positivity, an increased rate of pathological complete response, and improved disease-specific survival.
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