Liensinine alleviates high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) through suppressing oxidative stress and inflammation via regulating TAK1/AMPK signaling

Liping Liang,Shiwei Ye,Ruilai Jiang, Xiao Zhou,Junjie Zhou,Shuiyun Meng

International Immunopharmacology（2022）

引用 19|浏览3

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摘要

•Liensinine reduces lipid deposition and ROS produce in PA-incubated cells.•Liensinine mitigates inflammatory response in PA-stimulated cells.•Liensinine ameliorates NAFLD pathologies in HFD-fed mice.•Liensinine reduces lipid accumulation in liver of HFD-challenged mice.

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关键词

NAFLD,Liensinine (LIEN),Lipid deposition,Oxidative stress and inflammation,TAK1/AMPK

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