Effectiveness of ceftazidime-avibactam for the treatment of infections due to Pseudomonas aeruginosa

Laura Corbella, Jorge Boán,Rafael San-Juan,Mario Fernández-Ruiz,Octavio Carretero,David Lora,Pilar Hernández-Jiménez,María Ruiz-Ruigómez,Isabel Rodríguez-Goncer,José Tiago Silva,Francisco López-Medrano,Manuel Lizasoain,Jennifer Villa,Jose Manuel Caro-Teller,José María Aguado

International Journal of Antimicrobial Agents（2022）

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摘要

•Ceftazidime-avibactam (CAZ-AVI) is an effective and safe therapy for multidrug or extremely resistant (MDR/XDR) Pseudomonas aeruginosa infections•It is especially useful for strains with class A carbapenemase production•Early therapy with CAZ-AVI is associated with better outcomes•CAZ-AVI as part of combination therapy provides no clear benefits over monotherapy

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关键词

Ceftazidime-avibactam,Pseudomonas aeruginosa,Carbapenemase,Clinical cure,Mortality

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