Does RAD21 Co-Mutation Have a Role in DNMT3A Mutated AML? Results of Harmony Alliance AML Database

Raúl Azibeiro Melchor,Alberto Hernández Sánchez,Teresa González,Marta Sobas,Javier Martinez Elicegui,Angela Villaverde Ramiro,Axel Benner,Eric Sträng,Castellani Gastone,Caroline A. Heckman,Ana Heredia Casanoves,Jurjen Versluis,María Abáigar,Laura Jamilis,Peter JM Valk,Klaus H. Metzeler,Rosa Ayala,Herve Dombret,Jorge Sierra, Claude Preudomme

Blood（2021）

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摘要

Background: The development of new genetic profiling techniques such as Next Generation Sequencing (NGS) have helped to unravel the genomic landscape of a large number of hematological diseases. In acute myeloblastic leukemia (AML), many mutations have been found at diagnosis or during the course of the disease, either alone or in combination.

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关键词

AML,gene combinations,RAD21,DNMT3A,NPM1,HARMONY,big data

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